N,N-Dimethylaniline

  • N,N-Dimethylbenzenamine
  • (Dimethylamino)benzene
Formula C6H5N(CH3)2
Structure
Description Yellow to brownish, oily liquid, amine-like odor,.
Uses Manufacture of Michler's ketone, as reagent for methanol, methyl furfural, hydrogen peroxide, nitrate, alcohol, formaldehyde.

Registry Numbers and Inventories.
CAS 121-69-7
EC (EINECS/ELINCS) 204-493-5
EC Index Number 612-016-00-0
EC Class Carcinogenic Category 3; Toxic; Dangerous for the Environment
EC Risk Phrase R 23/24/25 40 51/53
EC Safety Phrase S 28 36/37 45 61
RTECS BX4725000
RTECS class Tumorigen; Mutagen; Human Data; Primary Irritant
UN (DOT) 2253
Merck 13,3261
Beilstein/Gmelin 507140
Beilstein Reference 4-12-00-00243
Swiss Giftliste 1 G-1557
Canada DSL/NDSL DSL
US TSCA Listed
Austrailia AICS Listed
New Zealand Listed
Japan ENCS (MITI) Listed

Properties.
Formula C8H11N
Formula mass 121.18
Melting point, C 2.5
Boiling point, C 194
Vapor pressure, mmHg 2.4 (40 C)
Vapor density (air=1) 4.17
Saturation Concentration 684 ppm (.07%) at 25 C (calculated)
Critical temperature 414
Critical pressure 35.8
Density 0.9559 g/cm3 (20 C)
Solubility in water Insoluble
Viscosity 1.405 cp (20 C)
Surface tension 36.46 g/s2 (20 C)
Refractive index 1.5582 (20 C)
pKa/pKb 8.85 (pKb)
Partition coefficient, pKow 2.31
Heat of fusion 11.82 kJ/mol
Heat of vaporization 53.98 kJ/mol
Heat of combustion -4766 kJ/mol

Hazards and Protection.
Storage Store in a cool, dry place. Store in a tightly closed container. Flammables-area. Do not store in metal containers.
Handling Wash thoroughly after handling. Wash hands before eating. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Ground and bond containers when transferring material. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Do not get on skin or in eyes. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Protection Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
Small spills/leaks Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, using the appropriate protective equipment. Scoop up with a nonsparking tool, then place into a suitable container for disposal. Remove all sources of ignition. Do not get water inside containers.
Disposal code 9
Stability Stable under normal temperatures and pressures.
Incompatibilities Metals, water, strong oxidizing agents.
Decomposition Carbon monoxide, oxides of nitrogen, irritating and toxic fumes and gases, carbon dioxide, hydrogen gas.

Fire.
Flash Point,C 75
Autoignition, C 370
Upper exp. limit, % 7
Lower exp. limit, % 1.2
Fire fighting Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water runoff can cause environmental damage. Dike and collect water used to fight fire. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Reacts with most metals to form highly flammable hydrogen gas which can form explosive mixtures with air. Water may be ineffective. Material is lighter than water and a fire may be spread by the use of water. Containers may explode in the heat of a fire. Extinguishing media: Water may be ineffective. Do NOT get water inside containers. For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray.
Fire potential May burn but does not ignite readily.
Hazards When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. May polymerize explosively when heated or involved in a fire. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Combustion products Toxic gases and vapors (such as carbon monoxide and oxides of nitrogen) may be released in a fire involving dimethylaniline.
NFPA Health 3
  Flammability 2  
  Reactivity 0  

Health.
Exposure limit(s) OSHA PEL: TWA 5 ppm (25 mg/m3) skin NIOSH REL: TWA 5 ppm (25 mg/m3) ST 10 ppm (50 mg/m3) skin NIOSH IDLH: 100 ppm
Poison_Class 2
Exposure effects Chronic ingestion may cause liver damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death.
   Ingestion Causes gastrointestinal irritation with nausea, vomiting and diarrhea. May cause systemic toxicity with acidosis. May cause methemoglobinemia, cyanosis, convulsions, and death. Exposure may cause anemia and other blood abnormalities. May be harmful if swallowed. May cause central nervous system depression.
   Inhalation May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. May cause effects similar to those described for ingestion. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown blood. Inhalation of aniline causes anoxia due to the formation of methemoglobinemia.
   Skin Causes skin irritation. May be absorbed through the skin in harmful amounts.
   Eyes May cause severe eye irritation. May result in corneal injury.

First aid
 
   Ingestion Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
   Inhalation Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
   Skin Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
   Eyes Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Transport.
UN number 2253
Response guide 153
Hazard class 6.1
Packing Group II  
USCG CHRIS Code DLL  
USCG Compatatibility Group 9 Aromatic amines
HS Code 2921 42 90  
Std. Transport # 4921628